The relationship between maternal anxiety due to the COVID-19 pandemic and children's anxiety following school reopening in the post-pandemic era: an analytical cross-sectional study (preprint)

Background Although infection rates and mortality have decreased, COVID-19-related anxiety persists in families, especially among mothers, even in the post-pandemic period. Maternal mental health issues may jeopardize various aspects of children's development. This study aims to explore the correlation between maternal COVID-related anxiety and their children's anxiety following the reopening of primary schools in the post-pandemic era.Methods This analytical cross-sectional study involved the selection of 305 pairs of mothers and children. Data collection instruments comprised demographic questionnaires as well as assessments for COVID-related anxiety and manifest anxiety. Statistical analyses encompassed independent t-tests, one-way analysis of variance (ANOVA), and multivariate regression.Results Children's manifest anxiety was predicted by maternal anxiety related to COVID-19 (B = 0.907, P < 0.001). Moreover, significant associations were observed between the mean difference in mothers' COVID anxiety scores and their educational attainment and occupation, as well as their children's education and age, residential area, and their husbands' education and occupation (P < 0.001). Conversely, no significant differences were detected in maternal COVID anxiety scores concerning maternal age, spouse's age, and child's gender (P > 0.05).Conclusions Given the study's findings, it is recommended that nurses and psychologists provide educational interventions for mothers who need psychological support.

COVID-19 Antibody Seroprevalence Among General Population and High-Risk Occupational Groups in Eighteen Cities of Iran (preprint)

Background: As the COVID-19 pandemic unfolded, rapid case increase was observed in multiple cities in Iran. However, in the absence of seroprevalence surveys, the true infection rate remains unknown. In this population-based study we assessed the seroprevalence of SARS-CoV-2 antibodies in eighteen cities of Iran.Methods: We randomly selected and invited study participants from the general population (N = 3,547) and occupations with high risk of COVID-19 exposure, defined as high-risk population (e.g., supermarket employees) (N = 5,391), in eighteen cities of Iran. SARS-CoV-2 ELISA kits were used to detect antibody against COVID-19. Crude, population weight adjusted, and test performance adjusted seroprevalence rates were estimated.Findings: The population weight adjusted and test performance adjusted prevalence rates of antibody seropositivity in general population were 13·1% (95% CI 11·6-14·8%) and 18·5% (95% CI 16·1-21·3%), respectively. The population-weighted seroprevalence estimate implies that 3,290,633 (95% CI 2,907185-3,709,167) individuals, from the eighteen included cities in this study, were infected by end of April 2020.The overall prevalence rate was higher among individuals aged ≥ 60 years (32·0%, 95% CI 23·9-40·8%) and with comorbidity condition (23·7%, 95% CI 18·5-28·8%). The estimated seroprevalence of SARS-CoV-2 antibodies varied greatly by city and the highest population test-adjusted prevalence rates were in Rasht 78·1% (95% CI 58·3-98·3%) and Qom (66·5%, 95% CI 39·9-95·4%) cities. The test-adjusted prevalence did not differ between low and high-risk populations and was about 20.0%.Interpretations: The findings of this study imply that prevalence of seropositivity is likely much higher than the reported prevalence rates based on confirmed COVID-19 cases in Iran. Despite the high seroprevalence rates in a few cities, the low overall prevalence estimates indicate that a large proportion of population is still susceptible to the virus. The similar seroprevalence estimates between low and high-risk occupations might be an indicator of inadequate or low adherence to infection control measures among general population.Funding Statement: Iranian Ministry of Health and Medical Education COVID-19 Grant (number 99-1-97-47964).Declaration of Interests: None to disclose.Ethics Approval Statement: Ethics approval for this study was granted by Vice-Chancellor in Research Affairs-Tehran University of Medical Sciences (IR. TUMS.VCR.REC.1399.308)